OF PROHORMONES IS 1AD
by ErgoPharm, Performance Nutrition Technology
are about to be introduced to the future of prohormones. It is called
1-AD, and it is without a doubt the single most amazing prohormone to be
synthesized and sold as a nutritional supplement.
Let’s start by setting something straight. We are not amateurs to the
prohormone industry. On the contrary, we actually started the whole
prohormone industry. But not only that, we are also responsible for
practically every significant innovation in prohormone technology to date.
The leader of ErgoPharm, organic chemist Patrick Arnold, was the person
who discovered androstenedione and introduced it to the market in 1996.
Patrick also discovered and patented Androdiol® (4-androstenediol) and
Norandrodiol® (19-nor-4-androstenediol), and introduced cyclodextrin
technology to the prohormone industry.
For the past 18 months Patrick has been feverishly working — almost
exclusively — on one project. While scores of less knowledgeable people in
the industry periodically made occasional lame, foul ball attempts at
finding the “latest, greatest” prohormone, Patrick kept quiet and worked
on the development of what essentially could be called the “holy grail” of
Patrick wanted this prohormone to have all the attributes most critical to
the perfect prohormone. It had to be:
- Orally Active
- Completely Non-Aromatizable to Estrogens
- Extremely potent
- Naturally occurring
After months of scouring every book and
journal he could locate, including those in foreign languages (i.e.
German), Patrick discovered a compound that seemed to be the perfect
candidate. That was the easy part. It then took Patrick almost one whole
year to figure out how to manufacture the compound cheaply enough for sale
as a supplement. Patrick’s lab took on the appearance of ground zero at
Hiroshima as he endlessly did reaction after reaction in pursuit of the
perfect manufacturing recipe.
Before we introduce exactly what 1-AD is, we want to mention one quick
thing. In this industry it is often hard to find straight answers to
exactly what something is, and how something works. Most often, the case
is that the company is evasive with the facts because there really is no
existing science that validates the claims they are making. Either that or
they simply do not understand the science themselves. Occasionally a
company does have science to back up their products, but they decide that
the consumer is too simple minded to appreciate the facts.
ErgoPharm is different. We produce products that are backed up by hard
scientific fact, and we take great pride in laying everything on the
We understand that not everyone buying our products has a chemistry or
biology degree, but we do know that people appreciate being treated with
respect and honesty. They want to know they are being told the straight
story, even if they don’t have the background to understand every facet of
It’s time to introduce what Patrick refers to as “the crown achievement”
of his career. The formal chemical name of the compound Patrick developed
is 1-androstene-3beta, 17beta-diol. We nicknamed this compound “1-AD”
which is a shortened acronym of its chemical name. Its chemical structure
This compound is truly unique amongst other
prohormones in a variety of ways. Let’s look specifically at 1-AD and what
The Power of 1-Testosterone
You probably are familiar with the “Andro” prohormones, and the “Norandro”
prohormones. The former convert to testosterone and the latter to
19-nortestosterone. 1-AD, however, does not fit into either of those
categories. That is because 1-AD converts to a relatively unheard of
hormone called 1-testosterone. 1-testosterone is what is known as a
“double bond isomer” of testosterone.
Although chemically the only difference between testosterone and
1-testosterone is the position of the double bond, pharmacologically the
two products are quite different. According to research done by the
pharmaceutical giant G.D. Searle and published in the 1960s,
1-testosterone is over 7 times as myotrophic (anabolic) as
testosterone(1). That makes 1-testosterone a phenomenally potent compound,
surpassing even most synthetic anabolic steroids.
1-testosterone differs from testosterone in another way as well. Being a
5alpha-reduced androgen (a DHT derivative) it simply cannot aromatize to
estrogens. The same goes for 1-AD itself — no estrogen transformation can
occur. This makes 1-AD unique compared to other prohormones — all of which
can either aromatize directly, convert to a product that aromatizes, or
both. So what does this mean in the real world? It means that your chances
of getting gynecomastia (bitch tits) from 1-AD is essentially zero, and
that water retention side effects are vastly reduced compared to other
The Only Truly “Orally Active” Prohormone
Natural androgenic steroids are normally not very active orally. Large
amounts have to be taken orally to see biological effects. This is because
the first pass through the liver causes a massive deactivation of the
compounds, primarily through the oxidation of the 17beta-hydroxyl to a
17-keto group. Chemists long ago found that by adding an alkyl (methyl or
ethyl) chemical group to the alpha position of the 17 carbon, this
oxidation can be prevented. However, this alkyl derivatization also
greatly increases the liver toxicity. Therefore the usage of such
synthetically altered compounds (methyltestosterone, oxymetholone,
stanozolol) are not without substantial risk.
Luckily, there are other ways to render a steroid orally active, and do so
without making the compound toxic to the liver. Certain structural
modifications can alter the metabolism of steroids making them resistant
to liver breakdown. One of these modifications is unsaturation (presence
of a double bond) in the 1-position. One steroid that has this structural
modification and is orally active is the anabolic steroid Methenolone,
also known as Primobolan.
As you may have noticed, this double bond
position that makes Primobolan orally active is the same one found in
1-AD, which, by the way, is also orally active. Steroids with this
particular double bond characteristic are known as 1-dehydroandrostanes.
During the 60’s and 70’s some papers were published describing the
phenomenon of oral activity seen with 1-dehydroandrostanes, including
1-testosterone and 1-AD. What was discovered was that these compounds
resist metabolic deactivation by profoundly shifting what is known as the
“17-keto redox potential” towards the formation of active 17beta-hydroxyl
steroids(2,3). What does this mean? It means that when you take 1-AD, the
liver serves primarily to activate the compound, rather than break it down
and excrete it as it does with other prohormones and testosterone. It
means that 1-AD is “orally active,” yet it does not impart the liver
toxicity that 17alpha-alkylation does.
A Natural Hormone Made in the Body
One of the beautiful things about 1-AD is that in addition to its
impressive pharmacological activity, it is also a natural androgen made in
the human body(4) . This means that it is not foreign to your body, and
that it can legally and openly be sold as a nutritional supplement.
Furthermore, 1-AD’s high rate of active conversion after oral
administration is not just a “theory” of ErgoPharm’s – it has been
demonstrated and published in a highly reputable peer reviewed journal.
Let’s put it all together and see what 1-AD has to offer:
- High oral activity
- Conversion to a hormone 700% more potent
- Absolutely NO aromatization to estrogens
- Natural and safe
There can be no argument that this is the
ultimate prohormone. Believe us, there simply are no natural compounds out
there that can come close to what 1-AD does, so don’t even bother looking.
1-AD is Now Available in Stores Near You
The ultimate prohormone is not just a dream anymore.1AD is now available
in stores near you. 1-AD is only available from ErgoPharm and can be found
in hardcore gyms and in health-food stores across the country.
1.Counsel et al., “Anabolic Agents.
Derivatives of 5alpha-Androst-1-ene”, J. Org. Chem., 27 (1962), 248-251
2. Galletti and Gardi, “Metabolism of 1-Dehydroandrostanes in Man”, J
Steroid Biochem, 3 (1972), 933-936
3. Langecker, “Beziehungen Zwischen Substitution im Ring A und Abbau im
Stoffwechsel bei Verwandten des Testosterons”, Acta Endocrin, 41 (1962),
4. Lieberman et al., J. Biol. Chem, 182 (1950), 299
5. Galletti and Gardi, “Metabolism of 1-Dehydroandrostanes in Man”, J
Steroid Biochem, 3 (1972), 933-936